Naturally derived biomaterials for development of composite bone scaffold: A review

Development of an antibacterial porous scaffold for bone defect treatment

Background & Aim: The use of bone scaffolds is one of the new and efficient techniques for repairing bone defects that provide a suitable platform for cell proliferation and growth to repair the target tissue. One of the most important causes of failure of transplants and surgical procedures is the invasion of bacteria at the site of the complication and the development of severe infection. The...

Cytotoxicity of Chitosan Derived from Shrimp for Bone Scaffold on Adipose Tissue-Derived Mesenchymal Stem Cells

Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials.

We have previously reported that an osteopontin-derived SVVYGLR peptide exhibited potent angiogenic activity in vitro and in vivo. In the present study, the focus points were on the in vitro effect of SVVYGLR on bone marrow stromal cell proliferation, as well as its in vivo effect on bone tissue formation when grafts made of CO3Ap-collagen sponge- as a scaffold biomaterial containing the SVVYGL...

Scaffold biomaterials for nano-pathophysiology.

This review is intended to provide an overview of tissue engineering strategies using scaffold biomaterials to develop a vascularized tissue engineered construct for nano-pathophysiology. Two primary topics are discussed. The first is the biological or synthetic microenvironments that regulate cell behaviors in pathological conditions and tissue regeneration. Second is the use of scaffold bioma...

biocompatibility study of a hydroxyapatite-alumina and silicon carbide composite scaffold for bone tissue engineering

objective: to date, several scaffolds have been fabricated for application in bone tissue repair. however, there remains a need for synthesis of scaffolds with better mechanical properties, which can be applied to defects in weight-bearing bones. we constructed a composite ceramic bioscaffold of hydroxyapatite-alumina and silicon carbide (ha-al2o3- sic) to take advantage of the mechanical prope...